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Symbol
Name
ID

Otx2
orthodenticle homeobox 2
MGI:97451

Phenotype annotations related to endocrine/exocrine glands

Darker colors indicate more annotations

Human Phenotypes	Decreased circulating ACTH concentration	Decreased response to growth hormone stimulation test	Ectopic posterior pituitary	Anterior pituitary hypoplasia	Ectopic anterior pituitary gland	Hypopituitarism	Abnormal prolactin level	Pituitary hypothyroidism	Absence of secondary sex characteristics	Delayed puberty	Hypogonadotropic hypogonadism
Disease(s) Associated with OTX2	Decreased circulating ACTH concentration	Decreased response to growth hormone stimulation test	Ectopic posterior pituitary	Anterior pituitary hypoplasia	Ectopic anterior pituitary gland	Hypopituitarism	Abnormal prolactin level	Pituitary hypothyroidism	Absence of secondary sex characteristics	Delayed puberty	Hypogonadotropic hypogonadism
panhypopituitarism
syndromic microphthalmia 5

Mouse Phenotypes		abnormal adenohypophysis morphology	abnormal gonadotroph morphology	decreased gonadotroph cell number	decreased testis weight
Availability	Mouse Genotype	abnormal adenohypophysis morphology	abnormal gonadotroph morphology	decreased gonadotroph cell number	decreased testis weight
	Otx2^tm1Pas/Otx2⁺
	Otx2^tm1Sia/Otx2⁺

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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